Herpes Simplex Virus Type 1 Preferentially Enhances Neuro-Inflammation and Senescence in Brainstem of Female Mice-Reference-Cited by-同舟云学术

Herpes Simplex Virus Type 1 Preferentially Enhances Neuro-Inflammation and Senescence in Brainstem of Female Mice

Published:2022-09-14 Issue:17 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Sivasubramanian Mahesh Kumar¹,Monteiro Raisa¹,Harrison Kelly S.²,Plakkot Bhuvana¹,Subramanian Madhan¹,Jones Clinton²^ORCID

Affiliation:

1. Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, Oklahoma, USA

2. Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, Oklahoma, USA

Abstract

HSV-1 (herpes simplex virus 1), an important human pathogen, establishes lifelong latency in neurons in trigeminal ganglia and the central nervous system. In contrast to productive infection, the only viral transcript abundantly expressed in latently infected neurons is the latency associated transcript (LAT).

Funder

HHS | NIH | NIH Office of the Director

HHS | NIH | National Institute of Neurological Disorders and Stroke

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01081-22

Reference87 articles.

1. Towards an Understanding of the Herpes Simplex Virus Type 1 Latency-Reactivation Cycle

2. HSV1 latent transcription and non-coding RNA: A critical retrospective