Variants in Bedaquiline-Candidate-Resistance Genes: Prevalence in Bedaquiline-Naive Patients, Effect on MIC, and Association with Mycobacterium tuberculosis Lineage-Reference-Cited by-同舟云学术

Variants in Bedaquiline-Candidate-Resistance Genes: Prevalence in Bedaquiline-Naive Patients, Effect on MIC, and Association with Mycobacterium tuberculosis Lineage

Published:2022-07-19 Issue:7 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Rivière Emmanuel¹²^ORCID,Verboven Lennert¹²,Dippenaar Anzaan¹^ORCID,Goossens Sander¹²^ORCID,De Vos Elise¹,Streicher Elizabeth³,Cuypers Bart²⁴^ORCID,Laukens Kris²,Ben-Rached Fathia⁵,Rodwell Timothy C.⁶⁷,Pain Arnab⁵⁸,Warren Robin M.³,Heupink Tim H.¹,Van Rie Annelies¹

Affiliation:

1. Tuberculosis Omics Research Consortium, Family Medicine and Population Health, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium

2. Adrem Data Lab, Department of Computer Science, Faculty of Sciences, University of Antwerp, Antwerp, Belgium

3. Division of Molecular Biology and Human Genetics, South African Medical Research Council Centre for Tuberculosis Research, DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa

4. Molecular Parasitology, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium

5. Computational Bioscience Research Centre, Biological Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia

6. FIND, Geneva, Switzerland

7. Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California San Diego, La Jolla, California, USA

8. International Institute for Zoonosis Control, Hokkaido University, Sapporo, Hokkaido, Japan

Abstract

Studies have shown that variants in bedaquiline-resistance genes can occur in isolates from bedaquiline-naive patients. We assessed the prevalence of variants in all bedaquiline-candidate-resistance genes in bedaquiline-naive patients, investigated the association between these variants and lineage, and the effect on phenotype.

Funder

Fonds Wetenschappelijk Onderzoek

National Research Foundation

South African Medical Research Council

Stellenbosch University Faculty of Medicine and Health Sciences

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00322-22

Reference42 articles.