Optimizing Meropenem in Highly Resistant Klebsiella pneumoniae Environments: Population Pharmacokinetics and Dosing Simulations in Critically Ill Patients-Reference-Cited by-同舟云学术

Optimizing Meropenem in Highly Resistant Klebsiella pneumoniae Environments: Population Pharmacokinetics and Dosing Simulations in Critically Ill Patients

Published:2022-11-15 Issue:11 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Truong Anh Quan¹^ORCID,Dao Xuan Co²,Vu Dinh Hoa¹^ORCID,Nguyen Hoang Anh¹³,Do Thi Hong Gam³,Tran Nhan Thang³,Tran Nhat Minh¹^ORCID,Vu Ngan Binh⁴,Pham Hong Nhung⁵,Bui Van Cuong²,Trinh The Anh²,Dang Quoc Tuan²,Nguyen Gia Binh²,Lipman Jeffrey⁶⁷⁸^ORCID,Cotta Menino O.⁶^ORCID,Roberts Jason A.⁶⁷⁸⁹^ORCID

Affiliation:

1. National Drug Information and Adverse Drug Reaction Monitoring Centre, Hanoi University of Pharmacy, Hanoi, Vietnam

2. Intensive Care Unit, Bach Mai Hospital, Hanoi, Vietnam

3. Department of Pharmacy, Bach Mai Hospital, Hanoi, Vietnam

4. Department of Analytical Chemistry and Toxicology, Hanoi University of Pharmacy, Hanoi, Vietnam

5. Department of Microbiology, Bach Mai Hospital, Hanoi, Vietnam

6. University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia

7. Department of Intensive Care Medicine, Royal Brisbane and Women’s Hospital, Brisbane, Queensland, Australia

8. Division of Anaesthesiology Critical Care Emergency and Pain Medicine, Nîmes University Hospital, University of Montpellier, Nîmes, France

9. Pharmacy Department, Royal Brisbane and Women’s Hospital, Brisbane, Queensland, Australia

Abstract

Critically ill patients are characterized by substantial pathophysiological changes that alter the pharmacokinetics (PK) of hydrophilic antibiotics, including carbapenems. Meropenem is a key antibiotic for multidrug-resistant Gram-negative bacilli, and such pathophysiological alterations can worsen treatment outcomes.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00321-22

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