Affiliation:
1. Mycology Division, Center for Disease Control, Public Health Service, U.S. Department of Health, Education, and Welfare, Atlanta, Georgia 30333
Abstract
Twenty isolates ofPrototheca filamenta, Prototheca moriformis, Prototheca stagnora, Prototheca wickerhamii, andPrototheca zopfiiwere tested for in vitro susceptibility to five commonly used antifungal agents: amphotericin B, 5-fluorocytosine, griseofulvin, miconazole, and nystatin. The results revealed resistance to griseofulvin of all theProtothecaisolates tested and an inhibitory effect onP. filamentaby high 5-fluorocytosine concentrations (minimal inhibitory concentration [MIC] = 12.5 to 100 μg/ml; minimal fungicidal or algacidal concentration [MFC/MAC] = 50 to 100 μg/ml).P. filamentaisolates were also susceptible to miconazole (MIC = 0.1 to 0.5 μg/ml, MFC/MAC = 0.5 to 1 μg/ml); isolates of the otherProtothecaspecies varied in regard to miconazole activity from susceptible to resistant (MIC = 1 − >100 μg/ml, MFC/MAC = 5 − >100 μg/ml). TheProtothecaisolates revealed an in vitro susceptibility to the polyene antifungal agents, amphotericin B, and nystatin (MIC = 0.09 to 3.12 μg/ml and 0.19 to 12.5 μg/ml, respectively; MFC/MAC = 0.19 to 25 μg/ml and 0.75 to 25 μg/ml, respectively).
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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