Affiliation:
1. Department of Experimental Therapeutics and Grace Cancer Drug Center, Roswell Park Memorial Institute, New York State Department of Health, Buffalo, New York 14263
Abstract
5-Ethyl-, 5-vinyl-, 5-propyl-, and 5-allyl-2′-deoxyuridine (dUrd) had antiviral activity against herpes simplex type 1 and type 2 grown in HeLa TK
−
cells, in the order 5-vinyl-dUrd, 5-ethyl-dUrd, 5-propyl-dUrd, 5-allyl-dUrd, but they were inactive against a TK
−
mutant of herpes simplex type 1. The antiviral activity of these compounds could be partially reversed by thymidine. Except for 5-vinyl-dUrd, they were not toxic to WI-38 and HeLa TK
−
cells at a concentration of 25 μM. All four analogues inhibited the growth of herpes simplex type 1-transformed HeLa TK
−
cells at a concentration of 1 μM.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference16 articles.
1. Virus type-specific thymidine kinase in cells biochemically transformed by herpes simplex virus types 1 and 2;Davis D. B.;J. Virol.,1974
2. Holland J. F. R. Korn J. O'Malley H. J. Minnemeyer and H. Tiechalmann. 1967. 5-Ally1-2'-deoxyu-ANTIMICROB. AGENTS CHEMOTHER.
3. ridine inhibition of nucleoside phosphorylase in HeLa
4. cells containins Mycoplasma. Cancer Res. 27:1867-
5. 1873.
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