Mice Fed Lipid-Encapsulated Mycobacterium bovis BCG Are Protected against Aerosol Challenge with Mycobacterium tuberculosis-Reference-Cited by-同舟云学术

Mice Fed Lipid-Encapsulated Mycobacterium bovis BCG Are Protected against Aerosol Challenge with Mycobacterium tuberculosis

Published:2005-03 Issue:3 Volume:73 Page:1903-1905
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Aldwell Frank E.¹,Brandt Lise²,Fitzpatrick Clare¹,Orme Ian M.²

Affiliation:

1. Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand

2. Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado

Abstract

ABSTRACT Mice that consumed a single dose of 10 7 lipid-encapsulated Mycobacterium bovis BCG bacilli showed significant pulmonary and systemic protection against aerosol challenge with M. tuberculosis H37Rv. As an extension of previous challenge studies with virulent strains of M. bovis , this report describes a reduction in M. tuberculosis infection in mice vaccinated orally with lipid-encapculated BCG comparable to that observed in mice vaccinated subcutaneously with BCG. These results are consistent with the induction of tuberculin-specific cell-mediated immune responses.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.73.3.1903-1905.2005

Reference16 articles.

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