Degradation of the Proapoptotic Proteins Bik, Puma, and Bim with Bcl-2 Domain 3 Homology in Chlamydia trachomatis -Infected Cells-Reference-Cited by-同舟云学术

Degradation of the Proapoptotic Proteins Bik, Puma, and Bim with Bcl-2 Domain 3 Homology in Chlamydia trachomatis -Infected Cells

Published:2005-03 Issue:3 Volume:73 Page:1861-1864
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Dong Feng¹,Pirbhai Mustak¹,Xiao Yangming¹,Zhong Youmin¹,Wu Yimou²,Zhong Guangming¹

Affiliation:

1. Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, San Antonio, Texas

2. Department of Microbiology, Nanhua University, Hengyang, Hunan, China

Abstract

ABSTRACT We have previously correlated Chlamydia trachomatis antiapoptotic activity with the blockade of mitochondrial cytochrome c release and the inhibition of Bax and Bak activation. We now report that C. trachomatis infection leads to degradation of Bik, Puma, and Bim, three upstream proapoptotic BH3-only proteins of the Bcl-2 family that can transmit death signals to mitochondria by inhibiting the Bcl-2 antiapoptotic proteins and/or activating the Bcl-2 proapoptotic members, such as Bax and Bak. This observation has provided new information on the chlamydial antiapoptosis mechanisms.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.73.3.1861-1864.2005

Reference20 articles.

1. Aho, T. L., J. Sandholm, K. J. Peltola, H. P. Mankonen, M. Lilly, and P. J. Koskinen. 2004. Pim-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper site. FEBS Lett.571:43-49.

2. Bouillet, P., and A. Strasser. 2002. BH3-only proteins—evolutionarily conserved proapoptotic Bcl-2 family members essential for initiating programmed cell death. J. Cell Sci.115:1567-1574.

3. Persistent Chlamydia trachomatis Infections Resist Apoptotic Stimuli

4. Cleavage of Host Keratin 8 by a Chlamydia-Secreted Protease

5. Inhibition of Apoptosis in Chlamydia-infected Cells: Blockade of Mitochondrial Cytochrome c Release and Caspase Activation

Cited by 93 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Insights into Chlamydia Development and Host Cells Response;Microorganisms;2024-06-26

2. Mitochondrial Dysfunction in Bacterial Infections;Pathogens;2023-08-01

3. Chlamydia Infection Remodels Host Cell Mitochondria to Alter Energy Metabolism and Subvert Apoptosis;Microorganisms;2023-05-24

4. Preparation and physicochemical properties of cisplatin and doxorubicin encapsulated by niosome alginate nanocarrier for cancer therapy;International Journal of Biological Macromolecules;2023-04

5. Expression profile screening and bioinformatics analysis of CircRNA, LncRNA, and mRNA in HeLa cells infected with Chlamydia muridarum;Archives of Microbiology;2022-05-27