Affiliation:
1. Departments of Experimental Pathology
2. Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas
Abstract
ABSTRACT
We performed GeneChip analyses on RNA from
Bacillus anthracis
lethal toxin (LeTx)-treated RAW 264.7 murine macrophages to investigate global effects of anthrax toxin on host cell gene expression. Stringent analysis of data revealed that the expression of several mitogen-activated protein kinase kinase-regulatory genes was affected within 1.5 h post-exposure to LeTx. By 3.0 h, the expression of 103 genes was altered, including those involved in intracellular signaling, energy production, and protein metabolism.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Cited by
33 articles.
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