Regulation of Cell Division in Bacteria by Monitoring Genome Integrity and DNA Replication Status

Author:

Burby Peter E.1,Simmons Lyle A.1

Affiliation:

1. Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA

Abstract

All organisms regulate cell cycle progression by coordinating cell division with DNA replication status. In eukaryotes, DNA damage or problems with replication fork progression induce the DNA damage response (DDR), causing cyclin-dependent kinases to remain active, preventing further cell cycle progression until replication and repair are complete.

Funder

HHS | National Institutes of Health

MoSTR | National Science Foundation

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Reference122 articles.

1. Metabolism, cell growth and the bacterial cell cycle

2. Friedberg EC, Walker GC, Siede W, Wood RD, Schultz RA, Ellenberger T. 2006. DNA repair and mutagenesis, 2nd ed. ASM Press, Washington, DC, p 463–497.

3. Mechanisms of DNA damage, repair, and mutagenesis

4. The DNA Damage Response: Making It Safe to Play with Knives

5. DNA-Damage Response in Tissue-Specific and Cancer Stem Cells

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