Activity of the Diaminopyrimidine AR-709 against Recently Collected Multidrug-Resistant Isolates of Invasive Streptococcus pneumoniae from North America-Reference-Cited by-同舟云学术

Activity of the Diaminopyrimidine AR-709 against Recently Collected Multidrug-Resistant Isolates of Invasive Streptococcus pneumoniae from North America

Published:2008-03 Issue:3 Volume:52 Page:1147-1149
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Ressner Roseanne A.¹,Moore Matthew R.²,Jorgensen James H.³

Affiliation:

1. Brooke Army Medical Center, Fort Sam Houston, Texas

2. Centers for Disease Control and Prevention, Atlanta, Georgia

3. University of Texas Health Science Center, San Antonio, Texas

Abstract

ABSTRACT Broth microdilution was used to determine the MICs of AR-709 and comparator antimicrobial agents for 224 invasive multidrug-resistant isolates of Streptococcus pneumoniae . AR-709 was highly active, with a MIC 50 of 0.25 μg/ml, a MIC 90 of 0.5 μg/ml, and a range of ≤0.008 μg/ml to 1 μg/ml.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01387-07

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