Effect of Diabetes Mellitus on the Pharmacokinetics and Pharmacodynamics of Tuberculosis Treatment

Author:

Alfarisi Omamah1,Mave Vidya12,Gaikwad Sanjay3,Sahasrabudhe Tushar4,Ramachandran Geetha5,Kumar Hemanth5,Gupte Nikhil12,Kulkarni Vandana2,Deshmukh Sona2,Atre Sachin4,Raskar Swapnil2,Lokhande Rahul3,Barthwal Madhusudan4,Kakrani Arjun4,Chon Sandy1,Gupta Amita12,Golub Jonathan E.1,Dooley Kelly E.1

Affiliation:

1. Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

2. Byramjee Jeejeebhoy Government Medical College-Johns Hopkins University Clinical Research Site, Pune, India

3. Byramjee Jeejeebhoy Government Medical College, Pune, India

4. Dr. D. Y. Patil Medical College, Hospital and Research Center, Dr. D. Y. Patil Vidyapeeth, Pimpri, Pune, India

5. National Institute for Research in Tuberculosis, Chennai, India

Abstract

Diabetes mellitus (DM) and tuberculosis (TB) are two common diseases with increasing geographic overlap and clinical interactions. The effect of DM and hemoglobin A1c (HbA1c) values on the pharmacokinetics (PK) and pharmacodynamics (PD) of anti-TB drugs remains poorly characterized.

Funder

HHS | National Institutes of Health

HHS | NIH | Fogarty International Center

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference72 articles.

1. World Health Organization. 2017. Global tuberculosis report 2017. World Health Organization Geneva Switzerland. http://www.who.int/tb/publications/global_report/en/. Accessed 3 May 2018.

2. World Health Organization. 2017. Diabetes. World Health Organization Geneva Switzerland. http://www.who.int/en/news-room/fact-sheets/detail/diabetes. Accessed 3 May 2018.

3. Association between diabetes mellitus and active tuberculosis: A systematic review and meta-analysis

4. Prevalence and associated factors of tuberculosis and diabetes mellitus comorbidity: A systematic review

5. Diabetic Control and Risk of Tuberculosis: A Cohort Study

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