Affiliation:
1. Institute of Veterinary Bacteriology, University of Bern, CH-3012 Bern, Switzerland
Abstract
ABSTRACT
A new gene,
sul3
, which specifies a 263-amino-acid protein similar to a dihydropteroate synthase encoded by the 54-kb conjugative plasmid pVP440 from
Escherichia coli
was characterized. Expression of the cloned
sul3
gene conferred resistance to sulfamethoxazole on
E. coli
. Two copies of the insertion element IS
15
Δ
/26
flanked the region containing
sul3
. The
sul3
gene was detected in one-third of the sulfonamide-resistant pathogenic
E. coli
isolates from pigs in Switzerland.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
261 articles.
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