Processing and localization of Dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5-Reference-Cited by-同舟云学术

Processing and localization of Dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5

Published:1992-12 Issue:12 Volume:66 Page:7549-7554
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Zhang L¹,Mohan P M¹,Padmanabhan R¹

Affiliation:

1. Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City 66103.

Abstract

Processing of dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5 could be mediated by the catalytically active NS3 protease domain and NS2B in trans at the dibasic sites NS3-NS4A and NS4B-NS5. Subcellular localization of the unprocessed precursor NS3-NS4A-NS4B-NS5 showed that it was confined to a distinct subcellular organelle in the cytoplasm, which was distinct from the distribution of the mature NS5.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.66.12.7549-7554.1992

Reference31 articles.

1. Brinton M. A. 1986. Replication of flaviviruses p. 327-365. In S. Schlesinger and M. J. Schlesinger (ed.) The Togaviridae and Flaviviridae. Plenum Press New York.

2. Cleavage of the dengue virus polyprotein at the NS3/NS4A and NS4B/NS5 junction is mediated by viral protease NS2B-NS3, whereas NS4AINS4B may be processed by a cellular protease;Cahour A.;J. Virol.,1992

3. Processing of the yellow fever virus nonstructural polyprotein: a catalytically active NS3 protease domain and NS2B are required for cleavages at dibasic sites;Chambers T. J.;J. Virol.,1991

4. Flavivirus genome organization expression, and replication. Annu;Chambers T. J.;Rev. Microbiol.,1990

5. Production of yellow fever virus proteins in infected cells: identification of discrete polyprotein species and analysis of cleavage kinetics using region-specific polyclonal antisera;Chambers T. J.;Virology,1990

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