In Vivo Activities of Farnesyl Pyrophosphate Synthase Inhibitors against Leishmania donovani and Toxoplasma gondii

Author:

Yardley Vanessa1,Khan Anis A.2,Martin Michael B.3,Slifer Teri R.2,Araujo Fausto G.2,Moreno Silvia N. J.4,Docampo Roberto4,Croft Simon L.1,Oldfield Eric35

Affiliation:

1. Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom

2. Department of Infectious Diseases, Palo Alto Medical Foundation, Palo Alto, California 94301

3. Department of Chemistry

4. Laboratory of Molecular Parasitology, Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802

5. Department of Biophysics, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801

Abstract

ABSTRACT The in vivo activities of three bisphosphonates were determined against Leishmania donovani and Toxoplasma gondii . Alendronate was essentially inactive against both parasites. Pamidronate was active against L. donovani by intravenous administration. Risedronate had a 50% effective dosage of five 2.6-mg/kg of body weight intraperitoneal doses against L. donovani- infected mice but was less effective against T. gondii -infected mice.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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