Antitrypanosomal Activities of Tryptanthrins-Reference-Cited by-同舟云学术

Antitrypanosomal Activities of Tryptanthrins

Published:2002-03 Issue:3 Volume:46 Page:882-883
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Scovill John¹,Blank Elizabeth¹,Konnick Michael¹,Nenortas Elizabeth²,Shapiro Theresa²

Affiliation:

1. Department of Chemistry, Bucknell University, Lewisburg, Pennsylvania 17837

2. Division of Clinical Pharmacology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2185

Abstract

ABSTRACT New drugs and molecular targets are needed against Trypanosoma brucei , the protozoan that causes African sleeping sickness. Tryptanthrin (indolo[2,1-b]quinazoline-6,12-dione), a traditional antifungal agent, and 11 analogs were tested against T. brucei in vitro. The greatest activity was conferred by electron-withdrawing groups in the 8 position of the tryptanthrin ring system; the most potent compound had a 50% effective concentration of 0.40 μM.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.46.3.882-883.2002

Reference14 articles.

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