Impact of Efavirenz-, Ritonavir-Boosted Lopinavir-, and Nevirapine-Based Antiretroviral Regimens on the Pharmacokinetics of Lumefantrine and Safety of Artemether-Lumefantrine in Plasmodium falciparum-Negative HIV-Infected Malawian Adults Stabilized on Antiretroviral Therapy-Reference-Cited by-同舟云学术

Impact of Efavirenz-, Ritonavir-Boosted Lopinavir-, and Nevirapine-Based Antiretroviral Regimens on the Pharmacokinetics of Lumefantrine and Safety of Artemether-Lumefantrine in Plasmodium falciparum-Negative HIV-Infected Malawian Adults Stabilized on Antiretroviral Therapy

Published:2018-11 Issue:11 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Banda Clifford G.¹²^ORCID,Dzinjalamala Fraction¹²,Mukaka Mavuto¹³⁴,Mallewa Jane¹²,Maiden Victor²,Terlouw Dianne J.²⁵,Lalloo David G.⁵,Khoo Saye H.⁶,Mwapasa Victor¹²

Affiliation:

1. University of Malawi, College of Medicine, Blantyre, Malawi

2. Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi

3. Oxford Centre for Tropical Medicine and Global Health, Oxford, United Kingdom

4. Mahidol-Oxford Tropical Medicine Research Unit, Bangkok, Thailand

5. Liverpool School of Tropical Medicine, Liverpool, United Kingdom

6. University of Liverpool, Liverpool, United Kingdom

Abstract

There is conflicting evidence of the impact of commonly used antiretroviral therapies (ARTs) on the pharmacokinetics of lumefantrine and the safety profile of artemether-lumefantrine. We compared the area under the concentration-time curve from 0 h to 14 days (AUC 0–14 days ) of lumefantrine and the safety profile of artemether-lumefantrine in malaria-negative human immunodeficiency virus (HIV)-infected adults in two steps.

Funder

European and Developing Countries Clinical Trials Partnership

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01162-18

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