Characterization of a myc-containing retrovirus generated by propagation of an MH2 viral subgenomic RNA

Author:

Martin P,Henry C,Ferre F,Bechade C,Begue A,Calothy C,Debuire B,Stehelin D,Saule S

Abstract

We have previously isolated, from wild-type MH2 virus that contains the two oncogenes mil and myc, mutants defective in one or the other oncogene product. We report here the molecular cloning and extensive characterization of MH2 CL25 provirus lacking the v-mil oncogene. Our results indicate that this virus corresponds to the propagation of the 2.8-kilobase subgenomic RNA of MH21.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Reference30 articles.

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2. Proliferation and transformation of chicken embryo neuroretina cells by retrovirus Mill Hill no. 2 (MH2) depends on the expression of the v-mil oncogene;Bechade C.;Nature (London),1985

3. Expression of viral oncogenes in differentiating chick embryo neuroretinal cells infected with avian tumor viruses;Calothy G.;Cold Spring Harbor Symp. Quant. Biol.,1979

4. Molecular cloning of the avian acute transforming retrovirus MH2 reveals a novel cell-derived sequence (v-mil) in addition to the myc oncogene;Coll J.;EMBO J.,1983

5. Molecular cloning and characterization of avian sarcoma virus circular DNA molecules;de Lorbe W. J.;J. Virol.,1980

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