Author:
Baskar J F,Stanat S C,Huang E S
Abstract
With the aim of illustrating a mechanism of cytomegalovirus (CMV) venereal transmission, we induced murine CMV infection in the mouse testes of immunologically competent mice. Using in situ cytohybridization, we were able to show that murine CMV-specific DNA was associated with spermatocytes and mature sperm. Electron microscopy studies also supported sperm infection. The virus could be reisolated from infected epididymal sperm by cocultivation with mouse embryo fibroblasts. We found no difference in either the sexual performance or the fertilization efficiency of the sperm between infected and uninfected males.
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
Reference29 articles.
1. Effect of murine cytomegalovirus on implantation stage mouse embryos;Baskar J. F.;Proc. Soc. Exp. Biol. Med.,1981
2. Baskar J. F. and E.-S. Huang. 1984. A mouse model for congenital defects and fetal maldevelopment p. 273-288. In F. Rapp (ed.) Herpesvirus UCLA Symposia on Molecular and Cellular Biology new series vol. 21. Alan R. Liss Inc. New York.
3. Cytomegalovirus infection of murine testicular interstitial Leydig cells;Baskar J. F.;Infect. Immun.,1983
4. Murine cytomegalovirus-induced congenital defects and fetal maldevelopment;Baskar J. F.;J. Infect. Dis.,1983
5. Seminal fluid excretion of cytomegalovirus related to immunosuppression in homosexual men;Biggar R. J.;Br. Med. J.,1983
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