Equine H7N7 influenza A viruses are highly pathogenic in mice without adaptation: potential use as an animal model

Author:

Kawaoka Y1

Affiliation:

1. Department of Virology and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38101.

Abstract

Equine H7N7 influenza A viruses, representing a broad range of isolates, were lethal in mice without adaptation. After repeated passages, A/Equine/London/1416/73 acquired neurotropism upon intranasal infection. Thus, mice infected with equine influenza A viruses provide a model system for the study of highly virulent mammalian influenza viruses.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Reference22 articles.

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