Molecular Markers of Sulfadoxine-Pyrimethamine Resistance in Samples from Children with Uncomplicated Plasmodium falciparum at Three Sites in Angola in 2019-Reference-Cited by-同舟云学术

Molecular Markers of Sulfadoxine-Pyrimethamine Resistance in Samples from Children with Uncomplicated Plasmodium falciparum at Three Sites in Angola in 2019

Published:2023-04-18 Issue:4 Volume:67 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Rosillo Stefano R.¹,Dimbu Pedro Rafael²,Cândido Ana Luisa M.³,Oh Je-Hoon Michael¹,Ferreira Carolina Miguel⁴,Nieto Andrade Benjamin⁴,Labuda Sarah⁵,Horth Roberta¹,Kelley Julia¹,Morais Joana F. M.³,Fortes Filomeno⁶,Martins José Franco²,Talundzic Eldin¹,Pluciński Mateusz M.¹⁷^ORCID

Affiliation:

1. Malaria Branch, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia, USA

2. National Malaria Control Program, Ministry of Health, Luanda, Angola

3. National Institute of Health Research, Ministry of Health, Luanda, Angola

4. Population Services International Angola, Luanda, Angola

5. United States President’s Malaria Initiative, U.S. Centers for Disease Control and Prevention, Luanda, Angola

6. Institute of Hygiene and Tropical Medicine, Nova University of Lisbon, Lisbon, Portugal

7. United States President’s Malaria Initiative, Malaria Branch, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia, USA

Abstract

Sulfadoxine-pyrimethamine (SP) is used for prevention of malaria in pregnant women in Angola. We sequenced the Plasmodium falciparum dihydrofolate reductase ( pfdhfr ) and dihydropteroate synthase ( pfdhps ) genes, implicated in SP resistance, in samples collected during a 2019 study of artemisinin-based combination therapy efficacy in Benguela, Lunda Sul, and Zaire provinces.

Funder

USAID | President's Malaria Initiative

AMD initiative CDC

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.01601-22

Reference27 articles.

1. Plasmodium falciparum drug resistance in Angola

2. Malaria in Angola: recent progress, challenges and future opportunities using parasite demography studies

3. World Health Organization. 2013. WHO policy brief for the implementation of intermittent preventive treatment of malaria in pregnancy using sulfadoxine-pyrimethamine (IPTp-SP). https://www.who.int/publications/i/item/WHO-HTM-GMP-2014.4. Accessed 1 December 2021.

4. World Health Organization. 2013. Meeting report of the Evidence Review Group on intermittent preventive treatment (IPT) of malaria in pregnancy. https://www.who.int/publications/m/item/meeting-report-of-the-evidence-review-group-on-intermittent-preventive-treatment-of-malaria-in-pregnancy. Accessed 1 December 2021.

5. The DHS Program. 2016. Angola: standard DHS 2015-16. https://dhsprogram.com/methodology/survey/survey-display-477.cfm. Accessed 1 December 2021.

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