Vaccination against Salmonella Infection: the Mucosal Way

Author:

Gayet Rémi1,Bioley Gilles2,Rochereau Nicolas1,Paul Stéphane1,Corthésy Blaise2

Affiliation:

1. Groupe Immunité des Muqueuses et Agents Pathogènes, Saint-Etienne, France

2. R&D Laboratory, Division of Immunology and Allergy, CHUV, Centre des Laboratoires d'Epalinges, Epalinges, Switzerland

Abstract

SUMMARY Salmonella enterica subspecies enterica includes several serovars infecting both humans and other animals and leading to typhoid fever or gastroenteritis. The high prevalence of associated morbidity and mortality, together with an increased emergence of multidrug-resistant strains, is a current global health issue that has prompted the development of vaccination strategies that confer protection against most serovars. Currently available systemic vaccine approaches have major limitations, including a reduced effectiveness in young children and a lack of cross-protection among different strains. Having studied host-pathogen interactions, microbiologists and immunologists argue in favor of topical gastrointestinal administration for improvement in vaccine efficacy. Here, recent advances in this field are summarized, including mechanisms of bacterial uptake at the intestinal epithelium, the assessment of protective host immunity, and improved animal models that closely mimic infection in humans. The pros and cons of existing vaccines are presented, along with recent progress made with novel formulations. Finally, new candidate antigens and their relevance in the refined design of anti- Salmonella vaccines are discussed, along with antigen vectorization strategies such as nanoparticles or secretory immunoglobulins, with a focus on potentiating mucosal vaccine efficacy.

Funder

Swiss Science Research Foundation

French National Research Agency

Funding from Rhone-Alpes region

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology,Infectious Diseases

Reference252 articles.

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