Zika Virus Subverts Stress Granules To Promote and Restrict Viral Gene Expression

Author:

Bonenfant Gaston1,Williams Nina1,Netzband Rachel1,Schwarz Megan C.2,Evans Matthew J.2,Pager Cara T.1

Affiliation:

1. Department of Biological Sciences, The RNA Institute, University at Albany-SUNY, Albany, New York, USA

2. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA

Abstract

Many viruses inhibit SGs. In this study, we observed that ZIKV restricts SG assembly, likely by relocalizing and subverting specific SG proteins to modulate ZIKV replication. This ZIKV-SG protein interaction is interesting, as many SG proteins are also known to function in neuronal granules, which are critical in neural development and function. Moreover, dysregulation of different SG proteins in neurons has been shown to play a role in the progression of neurodegenerative diseases. The likely consequences of ZIKV modulating SG assembly and subverting specific SG proteins are alterations to cellular mRNA transcription, splicing, stability, and translation. Such changes in cellular ribostasis could profoundly affect neural development and contribute to the devastating developmental and neurological anomalies observed following intrauterine ZIKV infection. Our study provides new insights into virus-host interactions and the identification of the SG proteins that may contribute to the unusual pathogenesis associated with this reemerging arbovirus.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of General Medical Sciences

Burroughs Wellcome Fund

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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