The Clostridium difficile spo0A Gene Is a Persistence and Transmission Factor

Author:

Deakin Laura J.1,Clare Simon1,Fagan Robert P.2,Dawson Lisa F.3,Pickard Derek J.1,West Michael R.1,Wren Brendan W.3,Fairweather Neil F.2,Dougan Gordon1,Lawley Trevor D.4

Affiliation:

1. Microbial Pathogenesis Laboratory, Wellcome Trust Sanger Institute, Hinxton, United Kingdom

2. Center for Molecular Microbiology and Infection, Imperial College of London, London, United Kingdom

3. Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, University of London, London, United Kingdom

4. Bacterial Pathogenesis Laboratory, Wellcome Trust Sanger Institute, Hinxton, United Kingdom

Abstract

ABSTRACT Clostridium difficile is a major cause of chronic antibiotic-associated diarrhea and a significant health care-associated pathogen that forms highly resistant and infectious spores. Spo0A is a highly conserved transcriptional regulator that plays a key role in initiating sporulation in Bacillus and Clostridium species. Here, we use a murine model to study the role of the C. difficile spo0A gene during infection and transmission. We demonstrate that C. difficile spo0A mutant derivatives can cause intestinal disease but are unable to persist within and effectively transmit between mice. Thus, the C. difficile Spo0A protein plays a key role in persistent infection, including recurrence and host-to-host transmission in mice.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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