Niche- and Gender-Dependent Immune Reactions in Relation to the Microbiota Profile in Pediatric Patients with Otitis Media with Effusion-Reference-Cited by-同舟云学术

Niche- and Gender-Dependent Immune Reactions in Relation to the Microbiota Profile in Pediatric Patients with Otitis Media with Effusion

Published:2020-09-18 Issue:10 Volume:88 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Enoksson Frida¹,Ruiz Rodriguez Alicia²,Peno Chikondi²,Balcazar Lopez Carlos²,Tjernström Fredrik³,Bogaert Debby²,Hakansson Anders P.⁴^ORCID,Bergenfelz Caroline⁴^ORCID

Affiliation:

1. Department of Otorhinolaryngology, Helsingborg Hospital, Helsingborg, Sweden

2. Centre for Inflammation Research, Queen’s Medical Institute, University of Edinburgh, Edinburgh, United Kingdom

3. Department of Otorhinolaryngology, Skåne University Hospital, Lund, Sweden

4. Department of Translational Medicine, Experimental Infection Medicine, Lund University, Malmö, Sweden

Abstract

Otitis media with effusion (OME) is a common inflammatory disease that primarily affects children. OME is defined as a chronic low-grade inflammation of the middle ear (ME), without any signs of infection and with effusion persisting in the ME for more than 3 months. The precise pathogenesis is, however, not fully understood. Here, we comprehensively characterized and compared the host immune responses (inflammatory cells and mediators) and the overall microbial community composition (microbiota) present in matched middle ear effusion (MEE) samples, external ear canal (EEC) lavages, and nasopharynx (NPH) samples from children with OME.

Funder

The Stig and Ragna Gorthon Foundation

The Spanish Foundation “Ramon Areces”

Vetenskapsrådet

Kungliga Fysiografiska Sällskapet i Lund

Crafoordska Stiftelsen

Svenska Sällskapet för Medicinsk Forskning

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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