Innate Protection of Mycobacterium smegmatis against the Antimicrobial Activity of Nitric Oxide Is Provided by Mycothiol-Reference-Cited by-同舟云学术

Innate Protection of Mycobacterium smegmatis against the Antimicrobial Activity of Nitric Oxide Is Provided by Mycothiol

Published:2007-09 Issue:9 Volume:51 Page:3364-3366
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Miller Christopher C.¹²,Rawat Mamta³,Johnson Todd³,Av-Gay Yossef¹

Affiliation:

1. Department of Medicine, Division of Infectious Diseases, University of British Columbia, Vancouver, BC, Canada

2. Pulmonox Medical Inc., Box 1020, Tofield, AB T0B 4J0, Canada

3. Department of Biology, California State University—Fresno, Fresno, California, 93740

Abstract

ABSTRACT Nitric oxide (NO) is an efficient antimicrobial agent. A role for mycothiol in protecting mycobacteria from nitrosative damage was revealed by showing that a Mycobacterium smegmatis mutant is sensitive to NO. A direct correlation between NO and mycothiol levels confirmed that mycothiol is important for protecting mycobacteria from NO attack.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00347-07

Reference19 articles.

1. Bryk, R., C. D. Lima, H. Erdjument-Bromage, P. Tempst, and C. Nathan. 2002. Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein. Science295:1073-1077.

2. Clementi, E., G. C. Brown, M. Feelisch, and S. Moncada. 1998. Persistent inhibition of cell respiration by nitric oxide: crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione. Proc. Natl. Acad. Sci. USA95:7631-7636.

3. Dosanjh, N. S., M. Rawat, J. H. Chung, and Y. Av-Gay. 2005. Thiol specific oxidative stress response in Mycobacteria. FEMS Microbiol. Lett.249:87-94.

4. Ghaffari, A., C. C. Miller, B. McMullin, and A. Ghahary. 2006. Potential application of gaseous nitric oxide as a topical antimicrobial agent. Nitric Oxide14:21-29.

5. Ghaffari, A., D. H. Neil, A. Ardakani, J. Road, A. Ghahary, and C. C. Miller. 2005. A direct nitric oxide gas delivery system for bacterial and mammalian cell cultures. Nitric Oxide12:129-140.

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