Nonstationary Pharmacokinetics of Caspofungin in ICU Patients-Reference-Cited by-同舟云学术

Nonstationary Pharmacokinetics of Caspofungin in ICU Patients

Published:2020-08-20 Issue:9 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Borsuk-De Moor Agnieszka¹,Sysiak-Sławecka Justyna²,Rypulak Elżbieta²,Borys Michał²,Piwowarczyk Paweł²,Raszewski Grzegorz³,Onichimowski Dariusz⁴,Czuczwar Mirosław²,Wiczling Paweł¹^ORCID

Affiliation:

1. Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, Gdańsk, Poland

2. 2nd Department of Anaesthesiology and Intensive Therapy, Medical University of Lublin, Lublin, Poland

3. Department of Physiopathology, Institute of Rural Health, Lublin, Poland

4. Department of Anaesthesiology and Intensive Therapy, Faculty of Medicine, University of Warmia and Mazury, Olsztyn, Poland

Abstract

Standard dosing of caspofungin in critically ill patients has been reported to result in lower drug exposure, which can lead to subtherapeutic 24-h area under the curve to MIC (AUC 0–24 /MIC) ratios. The aim of the study was to investigate the population pharmacokinetics of caspofungin in a cohort of 30 intensive care unit patients with a suspected invasive fungal infection, with a large proportion of patients requiring extracorporeal therapies, including extracorporeal membrane oxygenation (ECMO) and continuous renal replacement therapy (CRRT).

Funder

Uniwersytet Medyczny w Lublinie

Polpharma Scientific Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00345-20

Reference20 articles.

1. We can do better: a fresh look at echinocandin dosing

2. Clinical implications of antibiotic pharmacokinetic principles in the critically ill