Effect of beta-lactamase inhibitors on the activities of various beta-lactam agents against anaerobic bacteria-Reference-Cited by-同舟云学术

Effect of beta-lactamase inhibitors on the activities of various beta-lactam agents against anaerobic bacteria

Published:1991-06 Issue:6 Volume:35 Page:1219-1224
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Wexler H M¹,Molitoris E¹,Finegold S M¹

Affiliation:

1. Medical Service, Veterans Administration Wadsworth Medical Center, Los Angeles, California 90073.

Abstract

The in vitro activities of several new beta-lactam-beta-lactamase inhibitor combinations (piperacillin plus tazobactam, ceftizoxime and cefonicid with sulbactam and clavulanic acid, and ampicillin plus 8 micrograms of sulbactam per ml) were tested with anaerobic bacteria and compared with known beta-lactam-beta-lactamase inhibitor combinations and other potent antianaerobe agents. All the combinations tested (except for the cefonicid-inhibitor combinations) were active against almost all strains of the Bacteroides fragilis group. This report indicates that beta-lactamase inhibitors may improve the activity of beta-lactam agents with marginal activity against the B. fragilis group.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.35.6.1219

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