Structural Basis of the Main Proteases of Coronavirus Bound to Drug Candidate PF-07321332-Reference-Cited by-同舟云学术

Structural Basis of the Main Proteases of Coronavirus Bound to Drug Candidate PF-07321332

Published:2022-04-27 Issue:8 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Li Jian¹,Lin Cheng²,Zhou Xuelan³⁴,Zhong Fanglin³⁴,Zeng Pei³⁴,Yang Yang³,Zhang Yuting²,Yu Bo²,Fan Xiaona¹,McCormick Peter J.⁵,Fu Rui⁶,Fu Yang⁷,Jiang Haihai²^ORCID,Zhang Jin²^ORCID

Affiliation:

1. College of Pharmaceutical Sciences, Gannan Medical University, Ganzhou, China

2. School of Basic Medical Sciences, Nanchang University, Nanchang, China

3. Shenzhen Crystalo Biopharmaceutical Co., Ltd., Shenzhen, China

4. Jiangxi Jmerry Biopharmaceutical Co., Ltd., Ganzhou, China

5. William Harvey Research Institute, Bart’s and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

6. Jiangxi Provincial Children’s Hospital, Nanchang, China

7. School of Medicine, Southern University of Science and Technology, Shenzhen, China

Abstract

The current pandemic of multiple variants has created an urgent need for effective inhibitors of SARS-CoV-2 to complement vaccine strategies. PF-07321332, developed by Pfizer, is the first orally administered coronavirus-specific main protease inhibitor approved by the FDA.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.02013-21

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