Divergent HIV-1-Directed Immune Responses Generated by Systemic and Mucosal Immunization with Replicating Single-Cycle Adenoviruses in Rhesus Macaques-Reference-Cited by-同舟云学术

Divergent HIV-1-Directed Immune Responses Generated by Systemic and Mucosal Immunization with Replicating Single-Cycle Adenoviruses in Rhesus Macaques

Published:2019-05-15 Issue:10 Volume:93 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Matchett William E.¹,Anguiano-Zarate Stephanie S.²,Nehete Pramod N.³⁴,Shelton Kathryn³,Nehete Bharti P.³,Yang Guojun⁵,Dorta-Estremera Stephanie⁶,Barnette Philip⁷,Xiao Peng⁸,Byrareddy Siddappa N.⁹,Villinger Francois⁸,Hessell Ann J.⁷,Haigwood Nancy L.⁷,Sastry K. Jagannadha³⁵⁶⁴,Barry Michael A.¹⁰¹¹¹²

Affiliation:

1. Virology and Gene Therapy Graduate Program, Mayo Clinic, Rochester, Minnesota, USA

2. Clinical Translational Sciences Graduate Program, Mayo Clinic, Rochester, Minnesota, USA

3. Department of Comparative Medicine, The University of Texas M.D. Anderson Cancer Center, Houston and Bastrop, Texas, USA

4. The University of Texas M.D. Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences at Houston, Houston, Texas, USA

5. Department of Oncology Research for Biologics and Immunotherapy Translation, The University of Texas M.D. Anderson Cancer Center, Houston and Bastrop, Texas, USA

6. Department of Immunology, The University of Texas M.D. Anderson Cancer Center, Houston and Bastrop, Texas, USA

7. Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA

8. Department of Biology, New Iberia Research Center, Lafayette, Louisiana, USA

9. Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, USA

10. Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, USA

11. Department of Internal Medicine, Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA

12. Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA

Abstract

HIV-1 infections usually start at a mucosal surface after sexual contact. Creating a barrier of protection at these mucosal sites may be a good strategy for to protect against HIV-1 infections. While HIV-1 enters at mucosa, most vaccines are not delivered here. Most are instead injected into the muscle, a site well distant and functionally different than mucosal tissues. This study tested if delivering HIV vaccines at mucosa or in the muscle makes a difference in the quality, quantity, and location of immune responses against the virus. These data suggest that there are indeed advantages to educating the immune system at mucosal sites with an HIV-1 vaccine.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02016-18

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