Abstract
ABSTRACTThere are no wholly successful chemotherapeutic strategies againstBurkholderia cepaciacomplex (BCC) colonization in cystic fibrosis (CF). We assessed the impact of cysteamine (Lynovex) in combination with standard-of-care CF antibioticsin vitroagainst BCC CF isolates by the concentration at which 100% of bacteria were killed (MIC100) and checkerboard assays under CLSI standard conditions. Cysteamine facilitated the aminoglycoside-, fluoroquinolone- and folate pathway inhibitor-mediated killing of BCC organisms that were otherwise resistant or intermediately sensitive to these antibiotic classes. Slow-growing BCC strains are often recalcitrant to treatment and form biofilms. In assessing the impact of cysteamine on biofilms, we demonstrated inhibition of BCC biofilm formation at sub-MIC100s of cysteamine.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference30 articles.
1. Pseudomonas biofilms, cystic fibrosis, and phage: a silver lining?;mBio,2012
2. Antibiotic treatment for Burkholderia cepacia complex in people with cystic fibrosis experiencing a pulmonary exacerbation;Cochrane Database Syst Rev,2012
3. Infection control in cystic fibrosis: cohorting, cross-contamination, and the respiratory therapist;Respir Care,2009
4. Eradication therapy for Burkholderia cepacia complex in people with cystic fibrosis;Cochrane Database Syst Rev,2014
5. Burkholderia cepacia complex bacteria: opportunistic pathogens with important natural biology;J Appl Microbiol,2008
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