Prediction of Antimicrobial Resistance in Clinical Enterococcus faecium Isolates Using a Rules-Based Analysis of Whole-Genome Sequences-Reference-Cited by-同舟云学术

Prediction of Antimicrobial Resistance in Clinical Enterococcus faecium Isolates Using a Rules-Based Analysis of Whole-Genome Sequences

Published:2022-01-18 Issue:1 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Anahtar Melis N.¹²^ORCID,Bramante Juliet T.²³,Xu Jiawu²,Desrosiers Lisa A.¹,Paer Jeffrey M.²⁴,Rosenberg Eric S.¹⁵,Pierce Virginia M.¹⁶^ORCID,Kwon Douglas S.²⁵

Affiliation:

1. Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA

2. Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, USA

3. University of Washington School of Medicine, Seattle, Washington, USA

4. Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA

5. Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA

6. Pediatric Infectious Disease Unit, MassGeneral Hospital for Children, Boston, Massachusetts, USA

Abstract

Enterococcus faecium is a major cause of clinical infections, often due to multidrug-resistant (MDR) strains. Whole-genome sequencing (WGS) is a powerful tool to study MDR bacteria and their antimicrobial resistance (AMR) mechanisms.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01196-21

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