Modulation of Flavivirus Population Diversity by RNA Interference-Reference-Cited by-同舟云学术

Modulation of Flavivirus Population Diversity by RNA Interference

Published:2015-04 Issue:7 Volume:89 Page:4035-4039
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Brackney Doug E.¹,Schirtzinger Erin E.²,Harrison Thomas D.¹,Ebel Gregory D.¹,Hanley Kathryn A.²

Affiliation:

1. Arthropod-Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA

2. Department of Biology, New Mexico State University, Las Cruces, New Mexico, USA

Abstract

ABSTRACT To test the hypothesis that RNA interference (RNAi) imposes diversifying selection on RNA virus genomes, we quantified West Nile virus (WNV) quasispecies diversity after passage in Drosophila cells in which RNAi was left intact, depleted, or stimulated against WNV. As predicted, WNV diversity was significantly lower in RNAi-depleted cells and significantly greater in RNAi-stimulated cells relative to that in controls. These findings reveal that an innate immune defense can shape viral population structure.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02612-14

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