Detection and Characterization of Rotaviruses in Hospitalized Neonates in Blantyre, Malawi-Reference-Cited by-同舟云学术

Detection and Characterization of Rotaviruses in Hospitalized Neonates in Blantyre, Malawi

Published:2002-04 Issue:4 Volume:40 Page:1534-1537
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Cunliffe N. A.¹²³,Rogerson S.²,Dove W.³,Thindwa B. D. M.¹,Greensill J.³,Kirkwood C. D.⁴,Broadhead R. L.²,Hart C. A.³

Affiliation:

1. Wellcome Trust Research Laboratories, College of Medicine, Universities of Malawi and Liverpool

2. Department of Paediatrics, University of Malawi College of Medicine, Blantyre, Malawi

3. Department of Medical Microbiology and Genito-Urinary Medicine, University of Liverpool, Liverpool, United Kingdom

4. Department of Gastroenterology and Clinical Nutrition, Royal Children's Hospital, Melbourne, Australia

Abstract

ABSTRACT In five separate fecal collections spanning three years, group A rotaviruses were detected by enzyme-linked immunosorbent assay in 35 (25%) of 142 specimens obtained from nondiarrheic, hospitalized neonates in Blantyre, Malawi. Molecular characterization of each strain identified, for the first time in neonates, a short electropherotype, genotype P[6], G8 strain type, similar to the dominant, cocirculating community strain detected in symptomatic infants in Blantyre. Partial sequence analysis of the VP4 and NSP4 genes of neonatal and community strains failed to identify changes which could explain the differences in clinical outcome. Neonatal serotype G8 rotaviruses should be considered as potential rotavirus vaccine candidates for use in Malawi.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.40.4.1534-1537.2002

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