Phenotypic profile and functional characteristics of human gamma and delta T cells during acute toxoplasmosis-Reference-Cited by-同舟云学术

Phenotypic profile and functional characteristics of human gamma and delta T cells during acute toxoplasmosis

Published:1992-03 Issue:3 Volume:30 Page:729-731
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

De Paoli P¹,Basaglia G¹,Gennari D¹,Crovatto M¹,Modolo M L¹,Santini G¹

Affiliation:

1. Department of Microbiology and Immunology, General Hospital USL11, Pordenone, Italy.

Abstract

Gamma and delta (gamma delta) T-cell receptor lymphocytes are increased during acute toxoplasmosis. These cells are BB3+ CD45RO+ CD8-. Purified gamma delta T cells failed to proliferate in response to Toxoplasma gondii antigen (stimulation index, 1.4 +/- 0.6) but were responsive to phytohemagglutinin stimulation (stimulation index, 20.8 +/- 1.9). Natural-killer-like cytotoxicity was strongly acquired only after in vitro culture of purified gamma delta T cells with recombinant interleukin 2 (40% +/- 7% specific lysis). Our data show that gamma delta T-cell receptor T cells with a peculiar phenotype are increased during human acute T. gondii infection.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/jcm.30.3.729-731.1992

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