Corynebacterium group D2 as a cause of alkaline-encrusted cystitis: report of four cases and characterization of the organisms

Author:

Soriano F,Ponte C,Santamaria M,Aguado J M,Wilhelmi I,Vela R,Delatte L C

Abstract

In four patients with alkaline-encrusted cystitis, Corynebacterium group D2 was isolated from consecutive urine cultures and stones. Encrusted cystitis occurred in bladders harboring inflammatory or tumorous lesions in patients with chronic or recurrent urinary tract infections appearing after surgery or instrumentation. The urease activity of Corynebacterium group D2 and the neutralization of this enzyme by acetohydroxamic acid are shown. Clinical improvement, disappearance of struvite crystals, and decrease of the urine pH were obtained when these bacteria were eliminated from urine samples. Corynebacterium group D2 strains were highly resistant to many antimicrobial agents but were highly susceptible to norfloxacin and vancomycin when tested at two pHs (7.4 and 8.5).

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference13 articles.

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4. Urease: the primary cause of infection-induced urinary stones;Griffith D. P.;Invest. Urol.,1976

5. The etiology of incrusted cystitis with alkaline urine;Hager B. H.;J. Am. Med. Assoc.,1925

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