Distinct Origins and Transmission Pathways of bla KPC Enterobacterales across Three U.S. States

Author:

Lapp Zena1ORCID,Octaria Rany23,O’Malley Sean M.4,Nguyen Tu Ngoc5,Wolford Hannah6,Crawford Ryan1,Moore Christina3,Snippes Vagnone Paula4,Noel Diane5,Duffy Nadezhda6,Pirani Ali7,Thomas Linda S.3,Pattee Brittany4,Pearson Claire5,Bulens Sandra N.6,Hoffman Sophie1,Kainer Marion3,Anacker Melissa4,Meek James8,See Isaac6,Gontjes Kyle J.7,Chan Allison3,Lynfield Ruth4,Maloney Meghan5,Hayden Mary K.910,Snitkin Evan7ORCID,Slayton Rachel B.6

Affiliation:

1. Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA

2. Department of Medicine, Division of Epidemiology, Vanderbilt University, Nashville, Tennessee, USA

3. Tennessee Department of Health, Nashville, Tennessee, USA

4. Minnesota Department of Health, Saint Paul, Minnesota, USA

5. Connecticut Department of Public Health, Hartford, Connecticut, USA

6. Centers for Disease Control and Prevention, Atlanta, Georgia, USA

7. Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA

8. Connecticut Emerging Infections Program, Yale School of Public Health, New Haven, Connecticut, USA

9. Department of Medicine, Division of Infectious Diseases, Rush University Medical Center, Chicago, Illinois, USA

10. Department of Pathology, Rush University Medical Center, Chicago, Illinois, USA

Abstract

Carbapenem-resistant Enterobacterales (CRE) are among the most concerning antibiotic resistance threats due to high rates of multidrug resistance, transmissibility in health care settings, and high mortality rates. We evaluated the potential for regional genomic surveillance to track the spread of bla KPC -carrying CRE (KPC-CRE) by using isolate collections from health care facilities in three U.S. states.

Funder

HHS | Centers for Disease Control and Prevention

National Science Foundation

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference57 articles.

1. Centers for Disease Control and Prevention. 2019. Antibiotic resistance threats in the United States 2019. https://stacks.cdc.gov/view/cdc/82532. Accessed 11 June 2020.

2. Tracking the spread of carbapenem-resistantEnterobacteriaceae(CRE) through clinical cultures alone underestimates the spread of CRE even more than anticipated

3. World Health Organization. 2014. Antimicrobial resistance: global report on surveillance. World Health Organization, Geneva, Switzerland.

4. The rapid spread of carbapenem-resistant Enterobacteriaceae

5. Whole-Genome Sequencing To Identify Drivers of Carbapenem-Resistant Klebsiella pneumoniae Transmission within and between Regional Long-Term Acute-Care Hospitals

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