Quasispecies in wild-type tula hantavirus populations

Author:

Plyusnin A1,Cheng Y1,Lehväslaiho H1,Vaheri A1

Affiliation:

1. Haartman Institute, Department of Virology, University of Helsinki, Finland. Alexander.Plyusnin@helsinki.fi

Abstract

Tula virus (TUL) is a recently detected hantavirus carried by European common voles. Reverse transcriptase PCR cloning was used to study TUL S segment/N protein quasispecies. Both the distribution and character of mutations observed in three mutant spectra indicated limited selection at the protein level. At least 8% of the mutations were neutral or well tolerated; fixation of such mutations may play a role in TUL evolution in its natural host.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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