Characterization of M-Type-Specific Pilus Expression in Group A Streptococcus-Reference-Cited by-同舟云学术

Characterization of M-Type-Specific Pilus Expression in Group A Streptococcus

Published:2022-11-15 Issue:11 Volume:204 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Roshika Roshika¹,Jain Ira¹,Glenaldo Theodore¹,Sickler Tyler¹,Musser James M.²³⁴,Sumby Paul¹^ORCID

Affiliation:

1. Department of Microbiology & Immunology, University of Nevada, Reno School of Medicine, Reno, Nevada, USA

2. Laboratory of Molecular and Translational Human Infectious Disease Research, Center for Infectious Diseases, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, Houston, Texas, USA

3. Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York, USA

4. Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA

Abstract

Our ability to characterize how a pathogen infects and causes disease, and consequently our ability to devise approaches to prevent or attenuate such infections, is inhibited by the finding that isolates of a given pathogen often show phenotypic variability, for example, in their ability to adhere to host cells through modulation of cell surface adhesins. Such variability is observed between isolates of group A Streptococcus (GAS), and this study investigates the molecular basis for why some GAS isolates produce pili, cell wall-anchored adhesins, in lower abundance than other isolates do.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jb.00270-22

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