Analytical Method for Streptothricin-Type Antibiotics: Structure of Antibiotic LL-BL136-Reference-Cited by-同舟云学术

Analytical Method for Streptothricin-Type Antibiotics: Structure of Antibiotic LL-BL136

Published:1972-05 Issue:5 Volume:1 Page:403-407
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Borders D. B.¹,Kirby J. P.¹,Wetzel E. R.¹,Davies M. C.¹,Hausmann W. K.¹

Affiliation:

1. Process and Analytical Research Section, Lederle Laboratories, A Division of American Cyanamid Company, Pearl River, New York 10965

Abstract

An analytical procedure was devised which can distinguish members of the streptothricin family of antibiotics. It is based upon an analysis of the hydrolysis products of the antibiotics using a Technicon amino acid autoanalyzer under special conditions. The various fragments including the different streptolidine-amino sugar compounds were well resolved. A basic water-soluble antibiotic discovered in our laboratories and named LL-BL136 was compared to other members of this group by this technique. It was not differentiated from the antibiotic SF-701 reported by Tsuruoka. The autoanalyzer results along with other physicochemical data permitted a structure proposal for this antibiotic, which is the N -methyl-desformimino derivative of antibiotic LL-AC541.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.1.5.403

Reference7 articles.

1. Structures of LL-AC541 and LL-AB664. New streptothricintype antibiotics;Borders D. B.;Tetrahedron,1970

2. A method for the quantitative analysis of streptothricin hydrolysates;Egorov C. A.;J. Chromatogr.,1965

3. Studies on streptothricins. VII. Determnination of the ninhydrin-positive fragments of streptothricin antibiotics;Reshetov P. D.;Khim. Prir. Soedin.,1965

4. Technicon Corporation. 1961. Amino acids procedure. Ninhydrin p. 7-8. In Technicon autoanalyzer methodology section 1. Technicon Chromatography Corp. Chauncey N.Y.

5. Technicon Corporation. 1968. A new air stable ninhydrin reagent for use with standard Technicon amino acid analyzers. Research Bulletin no. 20. Technicon Chromatography Corp. Chauncey N.Y.

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