Hemagglutinin Stalk Immunity Reduces Influenza Virus Replication and Transmission in Ferrets-Reference-Cited by-同舟云学术

Hemagglutinin Stalk Immunity Reduces Influenza Virus Replication and Transmission in Ferrets

Published:2016-03-15 Issue:6 Volume:90 Page:3268-3273
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Nachbagauer Raffael¹²,Miller Matthew S.³,Hai Rong¹,Ryder Alex B.⁴,Rose John K.⁴,Palese Peter¹⁵,García-Sastre Adolfo¹⁵⁶,Krammer Florian¹,Albrecht Randy A.¹⁶

Affiliation:

1. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA

2. Faculty of Life Sciences, University of Vienna, Vienna, Austria

3. Department of Biochemistry and Biomedical Sciences, Institute for Infectious Diseases Research, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada

4. Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA

5. Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA

6. Global Health & Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA

Abstract

ABSTRACT We assessed whether influenza virus hemagglutinin stalk-based immunity protects ferrets against aerosol-transmitted H1N1 influenza virus infection. Immunization of ferrets by a universal influenza virus vaccine strategy based on viral vectors expressing chimeric hemagglutinin constructs induced stalk-specific antibody responses. Stalk-immunized ferrets were cohoused with H1N1-infected ferrets under conditions that permitted virus transmission. Hemagglutinin stalk-immunized ferrets had lower viral titers and delayed or no virus replication at all following natural exposure to influenza virus.

Funder

CEIRS

HHS | National Institutes of Health

PATH

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02481-15

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