Cryoelectron Microscopy Structures of AdeB Illuminate Mechanisms of Simultaneous Binding and Exporting of Substrates-Reference-Cited by-同舟云学术

Cryoelectron Microscopy Structures of AdeB Illuminate Mechanisms of Simultaneous Binding and Exporting of Substrates

Published:2021-02-23 Issue:1 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Morgan Christopher E.¹,Glaza Przemyslaw¹,Leus Inga V.²,Trinh Anhthu²,Su Chih-Chia¹,Cui Meng³,Zgurskaya Helen I.²,Yu Edward W.¹^ORCID

Affiliation:

1. Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

2. Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, USA

3. Department of Pharmaceutical Sciences, Northeastern University School of Pharmacy, Boston, Massachusetts, USA

Abstract

Acinetobacter baumannii has emerged as one of the most highly antibiotic-resistant Gram-negative pathogens. The prevalent AdeB multidrug efflux pump mediates resistance to a broad spectrum of clinically relevant antimicrobial agents.

Funder

HHS | NIH | Office of Extramural Research, National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.03690-20

Reference55 articles.

1. Multidrug-resistant Acinetobacter baumannii: mechanisms of virulence and resistance

2. Biology of Acinetobacter baumannii: Pathogenesis, Antibiotic Resistance Mechanisms, and Prospective Treatment Options

3. Carbapenem-resistantAcinetobacter baumannii: diversity of resistant mechanisms and risk factors for infection

4. CDC. 2019. Antibiotic resistance threats in the United States. CDC, Atlanta, GA.

5. Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis

Cited by 43 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Advances in microscopy-based techniques applied to the antimicrobial resistance of foodborne pathogens;Trends in Food Science & Technology;2024-10

2. Structural and functional diversity of Resistance-Nodulation-Division (RND) efflux pump transporters with implications for antimicrobial resistance;Microbiology and Molecular Biology Reviews;2024-09-05

3. Structural analysis of resistance-nodulation cell division transporters;Microbiology and Molecular Biology Reviews;2024-06-27

4. Recent advances in gene-editing approaches for tackling antibiotic resistance threats: a review;Frontiers in Cellular and Infection Microbiology;2024-06-26

5. AdeIJK Pump-Specific Inhibitors Effective against Multidrug Resistant Acinetobacter baumannii;ACS Infectious Diseases;2024-05-24