Genotyping of Pneumocystis jirovecii by Use of a New Simplified Nomenclature System Based on the Internal Transcribed Spacer Regions and 5.8S rRNA Gene of the rRNA Operon-Reference-Cited by-同舟云学术

Genotyping of Pneumocystis jirovecii by Use of a New Simplified Nomenclature System Based on the Internal Transcribed Spacer Regions and 5.8S rRNA Gene of the rRNA Operon

Published:2019-06 Issue:6 Volume:57 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Xue Ting¹,Ma Zhuang²,Liu Fan³,Du Wei-Qin⁴,He Li¹,Ma Liang⁵,An Chun-Li¹

Affiliation:

1. Department of Microbiology and Parasitology, College of Basic Medical Science, China Medical University, Shenyang, People’s Republic of China

2. Department of Respiratory Medicine, General Hospital of Shenyang Military Command, Shenyang, People’s Republic of China

3. Department of Respiratory Internal Medicine, First Affiliated Hospital of China Medical University, Shenyang, People’s Republic of China

4. Department of Clinical Laboratory, Eleventh Affiliated Hospital of Shanxi Medical University, Shanxi, People’s Republic of China

5. Critical Care Medicine Department, NIH Clinical Center, Bethesda, Maryland, USA

Abstract

Genotyping based on internal transcribed spacer 1 (ITS1) and ITS2 of the rRNA operon has played an important role in understanding the transmission and epidemiology of Pneumocystis jirovecii , one of the major opportunistic pathogens in individuals with AIDS and other immunocompromised individuals. The widespread use of this typing system has resulted in several problems, including inconsistent genotype nomenclatures, difficult data transferability, and complicated interpretation of the length variation in multiple homopolymeric tracts.

Funder

The Intramural Research Program of the U.S. National Institutes of Health Clinical Center

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.02012-18

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