Affiliation:
1. Evans Memorial Department of Clinical Research, Boston Medical Center, and Department of Medicine, Boston University School of Medicine, Boston, Massachusetts
Abstract
ABSTRACT
The antifungal activity of the nucleoside analog 3′-deoxyadenosine (cordycepin) was studied in a murine model of invasive candidiasis. When protected from deamination by either deoxycoformycin or coformycin, both of which are adenosine deaminase inhibitors, cordycepin exhibited potent antifungal efficacy, as demonstrated by prolongation of survival and a decrease in CFU in the kidneys of mice treated with cordycepin plus an adenosine deaminase inhibitor. The antifungal effect was seen with three different
Candida
isolates:
Candida albicans
64, a relatively fluconazole-resistant clinical isolate of
C. albicans
(MIC, 16 μg/ml), and the fluconazole-resistant
Candida krusei
. Cordycepin and related compounds may provide another avenue for the discovery of clinically useful antifungal drugs.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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