Bifidobacterium bifidum PRL2010 Modulates the Host Innate Immune Response

Abstract

ABSTRACTHere, we describe data obtained from transcriptome profiling of human cell lines and intestinal cells of a murine model upon exposure and colonization, respectively, withBifidobacterium bifidumPRL2010. Significant changes were detected in the transcription of genes that are known to be involved in innate immunity. Furthermore, results from enzyme-linked immunosorbent assays (ELISAs) showed that exposure toB. bifidumPRL2010 causes enhanced production of interleukin 6 (IL-6) and IL-8 cytokines, presumably through NF-κB activation. The obtained global transcription profiles strongly suggest thatBifidobacterium bifidumPRL2010 modulates the innate immune response of the host.