SmD1 Is Required for Spliced Leader RNA Biogenesis-Reference-Cited by-同舟云学术

SmD1 Is Required for Spliced Leader RNA Biogenesis

Published:2004-02 Issue:1 Volume:3 Page:241-244
ISSN:1535-9778
Container-title:Eukaryotic Cell
language:en
Short-container-title:Eukaryot Cell

Author:

Zeiner Gusti M.¹,Foldynová Silvie²,Sturm Nancy R.¹,Lukeš Julius²,Campbell David A.¹

Affiliation:

1. Department of Microbiology, Immunology & Molecular Genetics, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095-1489

2. Institute of Parasitology, Czech Academy of Sciences, and Faculty of Biology, University of South Bohemia, Ceské Budejovice, Czech Republic

Abstract

ABSTRACT The Sm-binding site of the kinetoplastid spliced leader RNA has been implicated in accurate spliced leader RNA maturation and trans -splicing competence. In Trypanosoma brucei , RNA interference-mediated knockdown of SmD1 caused defects in spliced leader RNA maturation, displaying aberrant 3′-end formation, partial formation of cap 4, and overaccumulation in the cytoplasm; U 28 pseudouridylation was unaffected.

Publisher

American Society for Microbiology

Subject

Molecular Biology,General Medicine,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/EC.3.1.241-244.2004

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