First Report of Candidemia Clonal Outbreak Caused by Emerging Fluconazole-Resistant Candida parapsilosis Isolates Harboring Y132F and/or Y132F+K143R in Turkey-Reference-Cited by-同舟云学术

First Report of Candidemia Clonal Outbreak Caused by Emerging Fluconazole-Resistant Candida parapsilosis Isolates Harboring Y132F and/or Y132F+K143R in Turkey

Published:2020-09-21 Issue:10 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Arastehfar Amir¹^ORCID,Daneshnia Farnaz²,Hilmioğlu-Polat Suleyha³^ORCID,Fang Wenjie⁴⁵,Yaşar Melike³^ORCID,Polat Furkan³,Metin Dilek Yeşim³,Rigole Petra⁶,Coenye Tom⁶^ORCID,Ilkit Macit⁷^ORCID,Pan Weihua⁴⁵,Liao Wanqing⁴⁵,Hagen Ferry²⁸^ORCID,Kostrzewa Markus⁹,Perlin David S.¹,Lass-Flörl Cornelia¹⁰,Boekhout Teun²¹¹^ORCID

Affiliation:

1. Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA

2. Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands

3. Division of Mycology, University of Ege, Izmir, Turkey

4. Second Military Medical University, Shanghai, China

5. Shanghai Key Laboratory Molecular Medical Mycology, Shanghai, China

6. Ghent University, Ghent, Belgium

7. Division of Mycology, University of Çukurova, Adana, Turkey

8. University Medical Center Utrecht, Utrecht, The Netherlands

9. Research and Development, Microbiology and Diagnostics, Bruker Daltonik GmbH, Bremen, Germany

10. Medical University of Innsbruck, Innsbruck, Austria

11. University of Amsterdam, Amsterdam, The Netherlands

Abstract

Clonal outbreaks of fluconazole-resistant (FLZR) Candida parapsilosis isolates have been reported in several countries. Despite its being the second leading cause of candidemia, the azole resistance mechanisms and the clonal expansion of FLZR C. parapsilosis blood isolates have not been reported in Turkey. In this study, we consecutively collected C. parapsilosis blood isolates ( n = 225) from the fifth largest hospital in Turkey (2007 to 2019), assessed their azole susceptibility pattern using CLSI M27-A3/S4, and sequenced ERG11 for all and MRR1 , TAC1 , and UPC2 for a selected number of C. parapsilosis isolates.

Funder

MOST | National Major Science and Technology Projects of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01001-20

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