Comparison of treatment outcomes between intermittent and daily regimens in non-cavitary nodular bronchiectatic-type <i>Mycobacterium avium</i> complex pulmonary disease in relation to sputum smear results: a retrospective cohort study-Reference-Cited by-同舟云学术

Comparison of treatment outcomes between intermittent and daily regimens in non-cavitary nodular bronchiectatic-type Mycobacterium avium complex pulmonary disease in relation to sputum smear results: a retrospective cohort study

Published:2023-11-15 Issue:11 Volume:67 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Jung Junghee¹^ORCID,Chong Yong Pil²^ORCID,Lee Hyun Joo³,Shim Tae Sun⁴^ORCID,Jo Kyung-Wook⁴^ORCID

Affiliation:

1. Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center , Seoul, South Korea

2. Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine , Seoul, South Korea

3. Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine , Seoul, South Korea

4. Department of Internal Medicine, Division of Pulmonology and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine , Seoul, South Korea

Abstract

ABSTRACT This study retrospectively analyzed the treatment outcomes of 110 patients with non-cavitary nodular bronchiectatic-type Mycobacterium avium complex pulmonary disease who received intermittent or daily treatment with a three-drug oral antibiotic regimen (i.e., a macrolide, ethambutol, and rifampin) at a tertiary referral center in South Korea. Among these patients, 36 had sputum smear positivity. Of these 36 patients, intermittent treatment led to a lower culture conversion rate than daily treatment [50.0% (8/16) vs 85.0% (17/20), P = 0.034].

Funder

National Research Foundation of Korea

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.01003-23

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