Impact of Early ARV Initiation on Relative Proportions of Effector and Regulatory CD8 T Cell in Mesenteric Lymph Nodes and Peripheral Blood During Acute SIV Infection of Rhesus Macaques-Reference-Cited by-同舟云学术

Impact of Early ARV Initiation on Relative Proportions of Effector and Regulatory CD8 T Cell in Mesenteric Lymph Nodes and Peripheral Blood During Acute SIV Infection of Rhesus Macaques

Published:2022-04-13 Issue:7 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Yero Alexis¹^ORCID,Farnos Omar¹,Clain Julien²,Zghidi-Abouzid Ouafa²,Rabezanahary Henintsoa²,Racine Gina²,Estaquier Jérôme²,Jenabian Mohammad-Ali¹^ORCID

Affiliation:

1. Department of Biological Sciences and CERMO-FC Research Centre, Université du Québec à Montréal (UQAM), Montreal, Quebec, Canada

2. Centre Hospitalier Universitaire (CHU) de Québec Research Center, Faculty of Medicine, Université Laval, Quebec City, Quebec, Canada

Abstract

Changes in CD8 T-cell subsets during acute SIV/HIV infections and following early ARV initiation in gut lymphoid tissues are poorly understood. Using an acute SIV infection model in rhesus macaques, we assessed the impact of early ARV, initiated 4 days postinfection, on relative proportions of CD8 T-cell subsets in MLNs compared to blood.

Funder

Canada Research Chairs

FRQ | Fonds de Recherche du Québec - Santé

Gouvernement du Canada | Canadian Institutes of Health Research

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00255-22

Reference64 articles.

1. CD8+ T-Cell Response to HIV Infection in the Era of Antiretroviral Therapy