In Vivo Generation of BK and JC Polyomavirus Defective Viral Genomes in Human Urine Samples Associated with Higher Viral Loads-Reference-Cited by-同舟云学术

In Vivo Generation of BK and JC Polyomavirus Defective Viral Genomes in Human Urine Samples Associated with Higher Viral Loads

Published:2021-05-24 Issue:12 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Addetia Amin¹²,Phung Quynh¹,Bradley Benjamin T.¹,Lin Michelle J.¹,Zhu Haiying¹,Xie Hong¹,Huang Meei-Li¹²,Greninger Alexander L.¹³^ORCID

Affiliation:

1. Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA

2. Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, Washington, USA

3. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

Abstract

Defective viral genomes (DVGs) can have a significant impact on the production of infectious virus particles. DVGs have only been identified in cultured viruses passaged at high multiplicities of infection and RNA viruses collected from clinical specimens; no DNA virus in the wild has been shown to contain DVGs.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00250-21

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