Characterization of I/F1 glycoprotein as a receptor for Mycoplasma pneumoniae-Reference-Cited by-同舟云学术

Characterization of I/F1 glycoprotein as a receptor for Mycoplasma pneumoniae

Published:1992-01 Issue:1 Volume:60 Page:79-83
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Hengge U R¹,Kirschfink M¹,König A L¹,Nicklas W¹,Roelcke D¹

Affiliation:

1. Institute of Immunology, University of Heidelberg, Germany.

Abstract

Serologic evidence of anti-I and anti-Fl cold agglutinins occurring in mycoplasma infections led to the isolation of I/Fl glycoprotein from human erythrocyte membranes. Mycoplasma pneumoniae bound to purified I/Fl glycoprotein in a dose-dependent fashion depending on sialylated carbohydrate determinants. This was shown by the decreased binding of mycoplasmas to either sialidase-treated I/Fl glycoprotein (dot blot analysis) or sialidase-treated erythrocytes (hemagglutination test). Structural properties of the receptor for optimal binding could be explored by hemagglutination inhibition assays. Glycophorins were excluded as receptors. These results indicate that Fl (and I) antigens are receptors for M. pneumoniae.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.60.1.79-83.1992

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